Abstract | OBJECTIVES: Clinical studies have indicated the beneficial effect of an L/ N-type calcium channel blocker (CCB), cilnidipine, on the progression of proteinuria in hypertensive patients compared with an L-type CCB, amlodipine. In the present study, we examined the effects of cilnidipine and amlodipine on the renal injury in spontaneously hypertensive rat/ND mcr-cp (SHR/ND) and their underlying mechanism. METHODS AND RESULTS: CONCLUSION:
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Authors | Yu-Yan Fan, Masakazu Kohno, Daisuke Nakano, Hiroyuki Ohsaki, Hiroyuki Kobori, Diah Suwarni, Naro Ohashi, Hirofumi Hitomi, Katsuhiko Asanuma, Takahisa Noma, Yasuhiko Tomino, Toshiro Fujita, Akira Nishiyama |
Journal | Journal of hypertension
(J Hypertens)
Vol. 28
Issue 5
Pg. 1034-43
(May 2010)
ISSN: 1473-5598 [Electronic] England |
PMID | 20411599
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Calcium Channel Blockers
- Calcium Channels, N-Type
- DNA Primers
- Dihydropyridines
- RNA, Messenger
- RNA, Small Interfering
- Triglycerides
- Amlodipine
- cilnidipine
- Creatinine
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Topics |
- Amlodipine
(pharmacology)
- Animals
- Base Sequence
- Blood Glucose
(metabolism)
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Calcium Channel Blockers
(pharmacology)
- Calcium Channels, N-Type
(drug effects, genetics, metabolism)
- Creatinine
(blood, urine)
- DNA Primers
(genetics)
- Dihydropyridines
(pharmacology)
- Disease Models, Animal
- Humans
- Kidney
(drug effects, metabolism, pathology)
- Male
- Metabolic Syndrome
(drug therapy, genetics, metabolism, pathology)
- Oxidative Stress
(drug effects)
- Podocytes
(drug effects, metabolism, pathology)
- Proteinuria
(prevention & control)
- RNA, Messenger
(genetics, metabolism)
- RNA, Small Interfering
(genetics)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Renin-Angiotensin System
(drug effects)
- Triglycerides
(blood)
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