Abstract | BACKGROUND: Epstein-Barr virus (EBV) has been discussed as a possible causative agent in inflammatory demyelinating diseases of the CNS. Cross-reactivity between EBV and myelin proteins has been proposed as a potential mechanism by which EBV could elicit an autoimmune response targeting the CNS. Recently, high antibody titers to native myelin oligodendrocyte glycoprotein (nMOG) were found in children affected by the first inflammatory demyelinating event. The relation between antibody responses to EBV and nMOG has not been addressed in children so far. METHODS: RESULTS: Serum IgG antibodies to EBNA-1 were present in 43% of controls (25/58), 42% of children with ADEM (8/19), and 64% of children with CIS (16/25), whereas IgM antibodies to EA were detected in only 16% of children with ADEM (3/19). High antibody titers to nMOG were only found in children with ADEM and CIS but were not related to the seropositivity to EBV. Moreover, in EBV-seropositive children, we did not observe any correlation between anti-EBNA-1 and anti-nMOG IgG antibody titers. CONCLUSION:
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Authors | R C Selter, F Brilot, V Grummel, V Kraus, S Cepok, R C Dale, B Hemmer |
Journal | Neurology
(Neurology)
Vol. 74
Issue 21
Pg. 1711-5
(May 25 2010)
ISSN: 1526-632X [Electronic] United States |
PMID | 20410464
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Epstein-Barr Virus Nuclear Antigens
- MOG protein, human
- Myelin Proteins
- Myelin-Associated Glycoprotein
- Myelin-Oligodendrocyte Glycoprotein
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Topics |
- Adolescent
- Antibodies, Viral
(immunology)
- Antibody Formation
(immunology)
- Child
- Child, Preschool
- Demyelinating Autoimmune Diseases, CNS
(complications, immunology, virology)
- Encephalitis
(complications, immunology, virology)
- Epstein-Barr Virus Nuclear Antigens
(immunology)
- Female
- Humans
- Infant
- Male
- Myelin Proteins
- Myelin-Associated Glycoprotein
(immunology)
- Myelin-Oligodendrocyte Glycoprotein
- Pediatrics
- Retrospective Studies
- Statistics, Nonparametric
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