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Protective role of thiol chelators against dimethylmercury induced toxicity in male rats.

Abstract
The present study was undertaken to establish mode of action, comparative therapeutic efficacy and safety evaluation of N-acetyl cysteine and dithiothreitol against acute dimethylmercury poisoning in rats. Male Sprague-Dawley albino rats (150 +/- 10 g) were randomly divided into six groups. Group 1 served as control. Group 2-4 were administered dimethylmercury (10 mg/kg, p.o.) once only and group 2 served as experimental control. Animals of group 3 and 4 were received N-acetyl cysteine and dithiothreitol. Compared to the control, significant increase (p < or = 0.05) was observed in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lipid peroxidation level and mercury ion concentration, however reduced glutathione, catalase, adenosine triphosphatase, acetyl cholinesterase (in brain only) were also decreased. It was concluded that N-acetyl cysteine provided maximum protection when compared with dithiothreitol group.
AuthorsDeepmala Joshi, Deepak Kumar Mittal, Sadhana Shrivastava, Sangeeta Shukla
JournalBulletin of environmental contamination and toxicology (Bull Environ Contam Toxicol) Vol. 84 Issue 5 Pg. 613-7 (May 2010) ISSN: 1432-0800 [Electronic] United States
PMID20401649 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Chelating Agents
  • Enzymes
  • Methylmercury Compounds
  • Sulfhydryl Compounds
  • dimethyl mercury
  • Dithiothreitol
  • Acetylcysteine
Topics
  • Acetylcysteine (pharmacology)
  • Animals
  • Brain (drug effects, enzymology)
  • Chelating Agents (chemistry, pharmacology)
  • Disease Models, Animal
  • Dithiothreitol (pharmacology)
  • Enzymes (metabolism)
  • Kidney (drug effects, enzymology)
  • Lipid Peroxidation
  • Liver (drug effects, enzymology)
  • Male
  • Mercury Poisoning, Nervous System (metabolism, prevention & control)
  • Methylmercury Compounds (toxicity)
  • Rats
  • Rats, Sprague-Dawley
  • Sulfhydryl Compounds (chemistry, pharmacology)

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