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Interdigitating dendritic cell sarcoma of the ileum recurred in multiple lymph nodes and duodenum three years after operation without chemotherapy.

Abstract
Neoplasms derived from interdigitating dendritic cell are extremely rare. Here we describe a case of a 47-year-old man with interdigitating dendritic cell sarcoma (IDCS) in the ileum. He was admitted to a hospital due to ileus. The ileal tumor, measuring 2cm, was detected and resected with regional lymphadenectomy. At that time, a pathologic diagnosis of malignant peripheral nerve sheath tumor was made. The patient, who was not treated with chemotherapy, showed no signs of recurrence. After three years, we detected cervical lymphadenopathy and multiple duodenal masses in the patient in our hospital. Oval to spindle-shaped atypical cells, which resembled ileal tumor cells, infiltrated into the lymph node and duodenum. Immunohistochemical staining of these three lesions revealed positivity of S100 protein and several macrophage-related antigens. Based on the histologic and immunohistochemical analysis, the histopathologic diagnosis of IDCS was confirmed. To our knowledge, five cases of IDCS arising in the intestinal tract have been reported to date, and only one case, treated with both surgery and chemotherapy, led to remission. This is the first case that has a comparatively favorable prognosis without chemotherapy after surgery.
AuthorsSonoko Ishihara, Yumi Honda, Tsuguharu Asato, Michiyasu Nonaka, Shigeki Nakagawa, Kotaro Hirashima, Naoko Hayashi, Hideo Baba, Ken-ichi Iyama
JournalPathology, research and practice (Pathol Res Pract) Vol. 206 Issue 7 Pg. 514-8 (Jul 15 2010) ISSN: 1618-0631 [Electronic] Germany
PMID20399026 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2010 Elsevier GmbH. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Biomarkers, Tumor
Topics
  • Antineoplastic Agents (therapeutic use)
  • Biomarkers, Tumor (analysis)
  • Dendritic Cell Sarcoma, Interdigitating (drug therapy, pathology, surgery)
  • Diagnostic Errors
  • Digestive System Surgical Procedures
  • Duodenal Neoplasms (drug therapy, pathology)
  • Humans
  • Ileal Neoplasms (pathology, surgery)
  • Immunohistochemistry
  • Lymph Nodes (pathology)
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (drug therapy, pathology, surgery)
  • Nerve Sheath Neoplasms (pathology)

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