Factors impacting the selection of antidepressant treatment in patients with major depressive disorder at risk for nonadherence.

Abstract

Treatment with the newer generation antidepressants is considered generally effective for most patients with major depressive disorder when taken in accordance with treatment guidelines. However, multiple clinical studies have demonstrated that rates of patient adherence to antidepressants are inadequate, specifically with regard to long-term maintenance treatment. Tolerability issues associated with antidepressants can increase the risk for patient nonadherence and result in subsequent relapse of depressive symptoms. Comorbid symptoms of anxiety also influence psychiatrists' choice of antidepressants for patients with depression. Physicians can improve long-term patient outcomes for patients with major depressive disorder by considering the possibility of drug-drug interactions before prescribing a specific antidepressant.

• Authors: Charles Shelton
• Journal: CNS spectrums (CNS Spectr) Vol. 14 Issue 12 Suppl 12 Pg. 15-9 (Dec 2009) ISSN: 1092-8529 [Print] United States
• PMID: 20397587 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antidepressive Agents

Topics

• Antidepressive Agents (adverse effects)
• Anxiety
• Depressive Disorder, Major (drug therapy, psychology)
• Female
• Humans
• Middle Aged
• Patient Compliance (psychology)
• Risk Factors