The diagnostic significance of lactate dehydrogenase isoenzymes in urinary cytology.

Abstract

Lactate dehydrogenase (LDH) isoenzyme distribution was examined in 106 urine samples being tested cytologically for evidence of bladder cancer; the samples were selected to have less than 20 leucocytes and erythrocytes per high power field and the LDH pattern determined by electrophoresis. The Papanicolaou stained-smears showed 68 negative, 17 suspicious and 21 positive. The LDH M-fraction of the urinary supernatant in cytologically positive cases was significantly greater than in negative cases, although the latter included a few false negative samples. Some of the false negatives gave positive results for the LDH M-fraction; these results suggest that the determination of LDH isoenzymes in the urine is useful in diagnosing urinary tract cancers, including early stage, and for follow-up of patients with bladder cancers after surgical resection.

• Authors: A Nishikawa, T Tanaka, T Takeuchi, S Fujihiro, H Mori
• Journal: British journal of cancer (Br J Cancer) Vol. 63 Issue 5 Pg. 819-21 (May 1991) ISSN: 0007-0920 [Print] England
• PMID: 2039708 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• L-Lactate Dehydrogenase

Topics

• Carcinoma, Transitional Cell (diagnosis, urine)
• Clinical Enzyme Tests
• Humans
• Isoenzymes
• L-Lactate Dehydrogenase (urine)
• Urinary Bladder Neoplasms (diagnosis, urine)