Abstract | BACKGROUND AND PURPOSE:
Intracranial thrombus is a principal feature in most ischemic stroke, and thrombus location and size may correlate with outcome and response to thrombolytic therapy. EP-2104R is a fibrin-specific molecular MR agent that has previously been shown to enhance extracranial and venous sinus thrombi in animal models and, recently, in clinical trials. In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi. METHODS: RESULTS: In all animals, MR angiography revealed a flow deficit and diffusion-weighted imaging showed hyperintensity consistent with ischemia. Using EP-2104R-enhanced MRI, we saw occlusive thrombi and vessel wall enhancement in all 6 animals with high contrast to noise relative to blood, whereas gadopentetate dimeglumine-injected animals showed no occlusive thrombus or vessel wall enhancement. The concentration of gadolinium in the thrombus after EP-2104R was 18 times that in the blood pool. CONCLUSIONS:
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Authors | Ritika Uppal, Ilknur Ay, Guangping Dai, Young Ro Kim, A Gregory Sorensen, Peter Caravan |
Journal | Stroke
(Stroke)
Vol. 41
Issue 6
Pg. 1271-7
(Jun 2010)
ISSN: 1524-4628 [Electronic] United States |
PMID | 20395615
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- EP-2104R
- Peptides
- Gadolinium
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Topics |
- Animals
- Brain Ischemia
(diagnostic imaging)
- Contrast Media
(pharmacology)
- Disease Models, Animal
- Gadolinium
(pharmacology)
- Intracranial Thrombosis
(diagnostic imaging)
- Magnetic Resonance Angiography
(methods)
- Male
- Peptides
(pharmacology)
- Radiography
- Rats
- Rats, Wistar
- Stroke
(diagnostic imaging)
- Thrombolytic Therapy
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