Relationship between residual symptoms of depression and self-reported cognitive impairment.

Abstract

OBJECTIVE:

The present study aimed to investigate the associations between residual symptoms of depression and specific self-reported symptoms in several cognitive domains.

METHODS:

The study investigated 117 patients with partially or fully remitted major depressive disorder (MDD) after treatment with antidepressant medications.

RESULTS:

Fatigue was significantly associated with inability to focus, alertness, and feeling "blue"; low interest and difficulty with concentration were associated with apathy. No associations were found between deficits in the cognitive domains considered and residual symptoms such as self-blaming, feeling worthless, feeling hopeless, having suicidal thoughts, difficulty with sleep, and lack of appetite.

CONCLUSION:

Among MDD remitted patients endorsing residual symptoms such as fatigue and feeling "blue", deficits in a range of cognitive domains should be carefully assessed and treated.

• Authors: Paola Pedrelli, Lee Baer, Dan V Losifescu, Maurizio Fava
• Journal: CNS spectrums (CNS Spectr) Vol. 15 Issue 1 Pg. 46-51 (Jan 2010) ISSN: 1092-8529 [Print] United States
• PMID: 20394184 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents

Topics

• Adult
• Antidepressive Agents (therapeutic use)
• Cognition Disorders (complications, psychology)
• Depression (complications, drug therapy)
• Fatigue (etiology)
• Feeding and Eating Disorders (etiology)
• Humans
• Middle Aged
• Neuropsychological Tests
• Personality Inventory
• Psychiatric Status Rating Scales
• Self Concept
• Sleep Wake Disorders (etiology)