Abstract | OBJECTIVE: DESIGN: Evaluation study. SAMPLE POPULATION: 599 canine and 347 feline urine samples. PROCEDURES: Urine was analyzed by use of dipstick, SSA, and UP:C methods; results were compared with those for a species-specific ELISA to determine sensitivity, specificity, positive predictive value (PPV), negative predictive value, and positive and negative likelihood ratios. RESULTS: Positive results for dipstick and SSA tests (trace reaction or greater) in canine urine had moderate specificity (dipstick, 81.2%; SSA, 73.3%) and poor PPV (dipstick, 34.0%; SSA, 41.8%). Values improved when stronger positive results (>or= 2+) for the dipstick and SSA tests were compared with ELISA results (specificity, 98.9% and 99.0% for the urine dipstick and SSA tests, respectively; PPV, 90.7% and 90.2% for the dipstick and SSA tests, respectively). Data obtained for cats revealed poor specificity (dipstick, 11.0%; SSA, 25.4%) and PPV (dipstick, 55.6%; SSA, 46.9%). Values improved slightly when stronger positive test results (>or= 2+) were used (specificity, 80.0% and 94.2% for the dipstick and SSA tests, respectively; PPV, 63.5% and 65.2% for the dipstick and SSA tests, respectively). The UP:C had high specificity for albuminuria in dogs and cats (99.7% and 99.2%, respectively) but low sensitivity (28.7% and 2.0%, respectively). CONCLUSIONS AND CLINICAL RELEVANCE: Caution should be used when interpreting a positive test result of a dipstick or SSA test for canine or feline albuminuria.
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Authors | Shane D Lyon, Michael W Sanderson, Shelly L Vaden, Michael R Lappin, Wayne A Jensen, Gregory F Grauer |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 236
Issue 8
Pg. 874-9
(Apr 15 2010)
ISSN: 0003-1488 [Print] United States |
PMID | 20392184
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzenesulfonates
- Reagent Strips
- Salicylates
- Creatinine
- sulfosalicylic acid
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Topics |
- Albuminuria
(diagnosis, veterinary)
- Animals
- Benzenesulfonates
- Cat Diseases
(diagnosis, urine)
- Cats
(urine)
- Creatinine
- Dog Diseases
(diagnosis, urine)
- Dogs
(urine)
- Enzyme-Linked Immunosorbent Assay
(veterinary)
- Proteinuria
(veterinary)
- Reagent Strips
- Salicylates
(chemistry)
- Sensitivity and Specificity
- Species Specificity
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