The complete genome sequence and molecular analysis of human hepatitis E virus genotype IV identified from a Korean patient.

Abstract

Hepatitis E virus (HEV) was originally identified as the etiological agent of non-HAV enterically transmitted hepatitis. One HEV strain (FJ763142) was identified from an acute viral hepatitis E patient with IgM anti-HEV in Korea. The complete genome sequence consisted of 7,238 nucleotides (nt) plus a 22-nt poly(A) tail. The strain belongs to genotype IV, with 91% homology compared with AB197674, which was found in a Japanese patient who had traveled to China. This finding suggests that HEV genotype IV already circulates in Korea, and this HEV might be the first example of an indigenous strain.

• Authors: Haesun Yun, Jin Seon Kim, Hyeok Jin Lee, Sook Hyang Jeong, Jeong Sim Kim, Sang Jong Park, Seong Gyu Hwang, Sook Kyoung Kang, Youngmee Jee, Jong Hyun Kim
• Journal: Archives of virology (Arch Virol) Vol. 155 Issue 6 Pg. 1003-8 (Jun 2010) ISSN: 1432-8798 [Electronic] Austria
• PMID: 20390311 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Base Sequence
• Female
• Genome, Viral
• Genotype
• Hepatitis E (virology)
• Hepatitis E virus (classification, genetics, isolation & purification)
• Humans
• Korea
• Middle Aged
• Molecular Sequence Data
• Phylogeny
• Sequence Analysis, DNA