[Phospholipid content of plasma membranes and phospholipase C activity in epithelial cells of the large intestine in colitis-associated carcinogenesis in rats].

Abstract

The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology--ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids' hydrolyzing enzyme--phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.

• Authors: O V Drobins'ka, O O Kravchenko, V A Koval'ova, O Iu Artemenko, L I Ostapchenko
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2009 Nov-Dec Vol. 81 Issue 6 Pg. 77-84 Ukraine
• PMID: 20387661 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phospholipids
• Dextran Sulfate
• Type C Phospholipases
• 1,2-Dimethylhydrazine
• Calcium

Topics

• 1,2-Dimethylhydrazine
• Animals
• Calcium (metabolism)
• Cell Membrane (enzymology, metabolism, pathology)
• Colitis, Ulcerative (complications, enzymology, metabolism, pathology)
• Colon (enzymology, metabolism, pathology)
• Colonic Neoplasms (enzymology, etiology, metabolism, pathology)
• Cytosol (metabolism)
• Dextran Sulfate
• Disease Models, Animal
• Epithelial Cells (enzymology, metabolism, pathology)
• Intestinal Mucosa (enzymology, metabolism, pathology)
• Male
• Phospholipids (metabolism)
• Rats
• Type C Phospholipases (metabolism)