Abstract | BACKGROUND: METHODS: Twelve 70-kg pigs had controlled insults to the thoracic aorta with and without heparin administration. The iatrogenic lesion was randomly covered with either TachoComb or TachoSil and the time to hemostasis was measured. RESULTS: Time to hemostasis when using TachoSil compared with TachoComb was increased 14% (-13% to 48%) with heparin and 10% (-26% to 66%) without heparin (mean +/- 95% confidence interval; p > 0.05 in both). Time to hemostasis with heparin administration increased significantly in both treatments: TachoComb 80% (26%-156%) (p = 0.001) and TachoSil 75% (18%-158%) (p = 0.005). CONCLUSION: We found neither statistical nor clinical evidence that TachoComb should have better hemostatic properties than does TachoSil in arterial bleeding. Both TachoSil and TachoComb can be used with heparin administration, but significant prolongation of the time to hemostasis is to be expected for both products. TachoSil should be preferred to TachoComb due to the potential lower risk of side effects when using the former.
|
Authors | Peter Agger, Jesper Langhoff, Morten H Smerup, J Michael Hasenkam |
Journal | The Journal of trauma
(J Trauma)
Vol. 68
Issue 4
Pg. 838-42
(Apr 2010)
ISSN: 1529-8809 [Electronic] United States |
PMID | 20386279
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Drug Combinations
- TachoSil
- tachocomb
- Fibrinogen
- Aprotinin
- Thrombin
|
Topics |
- Animals
- Aprotinin
(chemistry)
- Drug Combinations
- Female
- Fibrinogen
(chemistry)
- Hemorrhage
(therapy)
- Hemostasis, Surgical
(instrumentation)
- Pilot Projects
- Random Allocation
- Statistics, Nonparametric
- Swine
- Thrombin
(chemistry)
- Wounds, Stab
(therapy)
|