Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment.

Abstract

OBJECTIVE:

To compare assessment of regional cerebral metabolic changes with [(11)C]dihydrotetrabenazine (DTBZ)-positron emission tomography (PET) measurement of regional cerebral blood flow (K(1)) and fludeoxyglucose F18 (FDG)-PET measurement of regional cerebral glucose uptake (CMR(glc)) in a clinically representative sample of subjects with mild dementia and mild cognitive impairment (MCI).

DESIGN:

[(11)C]Dihydrotetrabenazine-PET K(1) and FDG-PET CMR(glc) measurements were performed.

SETTING:

University-based cognitive disorders clinic.

PARTICIPANTS:

Fifty subjects with either mild dementia (Mini-Mental State Examination score > or = 18) or MCI. Their results were compared with those of 80 normal control subjects.

MAIN OUTCOME MEASURES:

The DTBZ-PET regional K(1) and FDG-PET CMR(glc) measurements were compared with standard correlation analysis. The overall patterns of DTBZ-PET K(1) and FDG-PET CMR(glc) deficits were assessed with stereotaxic surface projections (SSPs) of parametric images.

RESULTS:

The DTBZ-PET regional K(1) and FDG-PET CMR(glc) measurements were highly correlated, both within and between subjects. The SSP maps of deficits in DTBZ-PET regional K(1) and FDG-PET CMR(glc) measurements were markedly similar. The DTBZ-PET K(1) SSP maps exhibited a mild decrease in sensitivity relative to FDG-PET CMR(glc) maps.

CONCLUSIONS:

Both DTBZ-PET K(1) and FDG-PET CMR(glc) measurements provide comparable information in assessment of regional cerebral metabolic deficits in mild dementia and MCI. Blood flow measures can assess regional cerebral metabolism deficits accurately in mild dementia and MCI. Blood flow assessments of regional cerebral metabolic deficits can be combined with tracer binding results to improve utility of PET imaging in mild dementia and MCI.

• Authors: Roger L Albin, Robert A Koeppe, James F Burke, Bruno Giordani, Michael R Kilbourn, Sid Gilman, Kirk A Frey
• Journal: Archives of neurology (Arch Neurol) Vol. 67 Issue 4 Pg. 440-6 (Apr 2010) ISSN: 1538-3687 [Electronic] United States
• PMID: 20385910 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Carbon Radioisotopes
• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• dihydrotetrabenazine
• Glucose
• Tetrabenazine

Topics

• Age of Onset
• Aged
• Aged, 80 and over
• Binding, Competitive (physiology)
• Brain Mapping (methods)
• Carbon Radioisotopes
• Cerebral Cortex (diagnostic imaging, metabolism, physiopathology)
• Cerebrovascular Circulation (physiology)
• Cognition Disorders (diagnostic imaging, metabolism, physiopathology)
• Dementia (diagnostic imaging, metabolism, physiopathology)
• Early Diagnosis
• Energy Metabolism (physiology)
• Female
• Fluorodeoxyglucose F18
• Glucose (metabolism)
• Humans
• Image Processing, Computer-Assisted (methods)
• Male
• Middle Aged
• Positron-Emission Tomography (methods)
• Predictive Value of Tests
• Radiopharmaceuticals
• Sensitivity and Specificity
• Tetrabenazine (analogs & derivatives)