Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Abstract

Familial Danish dementia (FDD) is a progressive neurodegenerative disease with cerebral deposition of Dan-amyloid (ADan), neuroinflammation, and neurofibrillary tangles, hallmark characteristics remarkably similar to those in Alzheimer's disease (AD). We have generated transgenic (tg) mouse models of familial Danish dementia that exhibit the age-dependent deposition of ADan throughout the brain with associated amyloid angiopathy, microhemorrhage, neuritic dystrophy, and neuroinflammation. Tg mice are impaired in the Morris water maze and exhibit increased anxiety in the open field. When crossed with TauP301S tg mice, ADan accumulation promotes neurofibrillary lesions, in all aspects similar to the Tau lesions observed in crosses between beta-amyloid (Abeta)-depositing tg mice and TauP301S tg mice. Although these observations argue for shared mechanisms of downstream pathophysiology for the sequence-unrelated ADan and Abeta peptides, the lack of codeposition of the two peptides in crosses between ADan- and Abeta-depositing mice points also to distinguishing properties of the peptides. Our results support the concept of the amyloid hypothesis for AD and related dementias, and suggest that different proteins prone to amyloid formation can drive strikingly similar pathogenic pathways in the brain.

• Authors: Janaky Coomaraswamy, Ellen Kilger, Heidrun Wölfing, Claudia Schäfer, Stephan A Kaeser, Bettina M Wegenast-Braun, Jasmin K Hefendehl, Hartwig Wolburg, Matthew Mazzella, Jorge Ghiso, Michel Goedert, Haruhiko Akiyama, Francisco Garcia-Sierra, David P Wolfer, Paul M Mathews, Mathias Jucker
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 107 Issue 17 Pg. 7969-74 (Apr 27 2010) ISSN: 1091-6490 [Electronic] United States
• PMID: 20385796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• ITM2B protein, human
• Membrane Glycoproteins
• Membrane Proteins

Topics

• Adaptor Proteins, Signal Transducing
• Alzheimer Disease (etiology, metabolism)
• Animals
• Blotting, Western
• Brain (metabolism)
• Dementia (etiology, metabolism)
• Disease Models, Animal
• Histological Techniques
• Immunoassay
• Membrane Glycoproteins
• Membrane Proteins (metabolism)
• Mice
• Mice, Transgenic
• Neuropsychological Tests