Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera.

Abstract

Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia.

• Authors: Joshua Parks, Thinley Gyeltshen, Vilailak Prachyawarakorn, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 5 Pg. 992-4 (May 28 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20384317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Benzoquinones
• Free Radical Scavengers
• Piperidones
• Terpenes
• cordiarimide A
• cordiarimide B
• globiferane
• Superoxides
• quinone
• Xanthine Oxidase
• Tetradecanoylphorbol Acetate

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Benzoquinones (chemistry, isolation & purification, pharmacology)
• Cordia (chemistry)
• Free Radical Scavengers (chemistry, isolation & purification, pharmacology)
• HL-60 Cells
• Humans
• Molecular Structure
• Piperidones (chemistry, isolation & purification, pharmacology)
• Plants, Medicinal (chemistry)
• Superoxides (metabolism)
• Terpenes (chemistry, isolation & purification, pharmacology)
• Tetradecanoylphorbol Acetate (pharmacology)
• Thailand
• Xanthine Oxidase (drug effects, metabolism)