Doxofylline: a "novofylline".

Abstract

Xanthines such as theophylline have been used in the treatment of lung diseases since the early 1900's, but have a major drawback of a very narrow therapeutic window and many drug/drug interactions. With the increasing availability of other classes of drugs, this has limited the use of xanthines. Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as theophylline and the evidence supporting the effects of doxofylline in the treatment of lung diseases is discussed.

• Authors: Clive P Page
• Journal: Pulmonary pharmacology & therapeutics (Pulm Pharmacol Ther) Vol. 23 Issue 4 Pg. 231-4 (Aug 2010) ISSN: 1522-9629 [Electronic] England
• PMID: 20380886 (Publication Type: Journal Article, Review)
• Copyright: Copyright (c) 2010. Published by Elsevier Ltd.

Chemical References

• Anti-Inflammatory Agents
• Bronchodilator Agents
• Theophylline
• doxofylline

Topics

• Animals
• Anti-Inflammatory Agents (adverse effects, pharmacology, therapeutic use)
• Bronchodilator Agents (adverse effects, pharmacology, therapeutic use)
• Clinical Trials as Topic
• Drug Interactions
• Humans
• Lung Diseases (drug therapy, physiopathology)
• Theophylline (adverse effects, analogs & derivatives, pharmacology, therapeutic use)