Perspectives for novel mixed diruthenium-organic drugs as metallopharmaceuticals in cancer therapy.

Abstract

Ruthenium compounds have been actively studied as metallodrugs for cancer therapy. Representatives of ruthenium-based antitumor drugs are the classes of ruthenium(III)-chlorido-(N-ligand) complexes, including the drugs namely NAMI-A and KP1019 in clinical trials, and ruthenium(II)-arene organometallics, with some compounds currently undergoing advanced preclinical testing. An alternative approach for tumor-inhibiting metallodrugs is the coordination of metal ions to organic pharmaceuticals. The combination of antitumor-active ruthenium ion with biologically-active pro-ligands in single compounds can result in the enhancement of activity, for example through synergistic effects. In the present article, some developments in the ruthenium-based antitumor drugs field are briefly highlighted and recent studies on mixed diruthenium-organic drugs as metallopharmaceuticals in cancer therapy are described. Novel organic pharmaceuticals-containing diruthenium(II,III) complexes have shown promising antitumor activity for C6 rat glioma - a model for glioblastoma multiforme (GBA).

• Authors: Denise de Oliveira Silva
• Journal: Anti-cancer agents in medicinal chemistry (Anticancer Agents Med Chem) Vol. 10 Issue 4 Pg. 312-23 (May 2010) ISSN: 1875-5992 [Electronic] Netherlands
• PMID: 20380636 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Indazoles
• Ligands
• Organometallic Compounds
• Organoplatinum Compounds
• Ruthenium Compounds
• imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)
• indazolium trans-(tetrachlorobis(1H-indazole)ruthenate (III))
• Ruthenium
• Dimethyl Sulfoxide

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (chemistry)
• Antineoplastic Agents (therapeutic use)
• Dimethyl Sulfoxide (analogs & derivatives, therapeutic use)
• Glioblastoma (drug therapy)
• Humans
• Indazoles (therapeutic use)
• Ligands
• Neoplasms (drug therapy)
• Organometallic Compounds (therapeutic use)
• Organoplatinum Compounds (therapeutic use)
• Rats
• Ruthenium (chemistry, therapeutic use)
• Ruthenium Compounds
• Solubility