HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Continuous positive airway pressure treatment in patients with sleep apnoea: does it really improve glucose metabolism?

Abstract
Obstructive Sleep Apnoea Syndrome (OSAS) is a common disorder, characterised by repetitive episodes of partial or complete obstruction of the upper airway during sleep and associated with increasing respiratory efforts. These perturbations lead, in turn, to oxyhaemoglobin desaturation, sleep fragmentation, and daytime symptoms, mainly excessive sleepiness. Accumulating evidence suggests that intermittent hypoxia and oxyhaemoglobin desaturation may result, independently of obesity, in impaired glucose metabolism, as well as insulin resistance even in non-diabetic patients with OSAS. Additionally, OSAS has been proposed as an independent risk factor for type 2 diabetes mellitus. Continuous Positive Airway Pressure (CPAP) is the treatment of choice for OSAS, since it eliminates upper airway collapse during sleep and also improves sleep fragmentation, daytime symptoms and quality of life. Moreover, it has been proposed that the amelioration of breathing disturbances during sleep can improve several markers of glucose metabolism and insulin resistance, such as glycated haemoglobin, fasting glucose, insulin, and insulin resistance. Indeed, some studies have reported improvements in these parameters especially in compliant patients. However, other works failed to confirm this beneficial effect. The present article reviews the issue whether CPAP treatment exerts a beneficial effect on glucose metabolism and insulin resistance.
AuthorsPaschalis Steiropoulos, Nikolaos Papanas, Evangelia Nena, Efstratios Maltezos, Demosthenes Bouros
JournalCurrent diabetes reviews (Curr Diabetes Rev) Vol. 6 Issue 3 Pg. 156-66 (May 2010) ISSN: 1875-6417 [Electronic] United Arab Emirates
PMID20380627 (Publication Type: Journal Article, Review)
Chemical References
  • Glucose
Topics
  • Continuous Positive Airway Pressure
  • Glucose (metabolism)
  • Glucose Metabolism Disorders (etiology, prevention & control)
  • Humans
  • Insulin Resistance
  • Sleep Apnea Syndromes (complications, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: