Caripyrin, a new inhibitor of infection-related morphogenesis in the rice blast fungus Magnaporthe oryzae.

Abstract

Caripyrin (trans-5-(3-methyloxiranyl)pyridincarboxylic acid methyl ester, 1), a new pyridyloxirane, was isolated from submerged cultures of the basidiomycete Caripia montagnei. The compound was found to inhibit conidial germination and appressorium formation in the rice blast fungus Magnaporthe oryzae, whereas the infection-related morphogenesis in several other phytopathogenic fungi was not affected. In plant assays on rice, 1 was found to protect plants more efficiently against fungal infection than the structurally related fungal secondary metabolite, fusaric acid. Contrary to the latter, 1 was neither cytotoxic, antibacterial, nor nematicidal.

• Authors: Patrick H Rieger, Johannes C Liermann, Till Opatz, Heidrun Anke, Eckhard Thines
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 63 Issue 6 Pg. 285-9 (Jun 2010) ISSN: 1881-1469 [Electronic] England
• PMID: 20379215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Epoxy Compounds
• Pyridines
• trans-5-(3-methyloxiranyl)pyridincarboxylic acid methyl ester

Topics

• Antifungal Agents (isolation & purification, pharmacology)
• Basidiomycota (metabolism)
• Epoxy Compounds (isolation & purification, pharmacology)
• Fermentation
• Magnaporthe (drug effects)
• Morphogenesis (drug effects)
• Oryza (growth & development, microbiology)
• Plant Diseases (prevention & control)
• Pyridines (isolation & purification, pharmacology)