Field trial of oral cholera vaccines in Bangladesh: serum vibriocidal and antitoxic antibodies as markers of the risk of cholera.

The relationship of serum vibriocidal (VC) and IgG anti-cholera toxin (CT) antibodies to the risk of cholera was evaluated during the first year of follow-up of recipients of three oral doses of B subunit (BS)-whole-cell vaccine, whole-cell vaccine, or Escherichia coli K12 strain placebo in Bangladesh. Acute sera from 121 cholera patients were compared with sera from 2592 contemporaneous community controls. Each doubling of VC titer was associated, on average, with a 22%-47% reduction of cholera risk in the three groups. In contrast, in the two groups that did not receive BS, anti-CT titers were directly associated with cholera and thus served as markers of higher cholera risk. Each vaccine conferred approximately 65% protective efficacy against cholera, but antibody titers did not correlate with vaccine efficacy, indicating that serum VC and anti-CT antibodies are poor markers of the longitudinal pattern of vaccine efficacy.
AuthorsJ D Clemens, F van Loon, D A Sack, J Chakraborty, M R Rao, F Ahmed, J R Harris, M R Khan, M Yunus, S Huda
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 163 Issue 6 Pg. 1235-42 (Jun 1991) ISSN: 0022-1899 [Print] UNITED STATES
PMID2037789 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Antibodies, Bacterial
  • Cholera Vaccines
  • Immunoglobulin G
  • Cholera Toxin
  • Administration, Oral
  • Adolescent
  • Adult
  • Age Factors
  • Antibodies, Bacterial (blood)
  • Bangladesh
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cholera (epidemiology, prevention & control)
  • Cholera Toxin (immunology)
  • Cholera Vaccines (administration & dosage, immunology)
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G (analysis)
  • Male
  • Middle Aged
  • Regression Analysis
  • Risk Factors
  • Vibrio cholerae (immunology)

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