Abstract | BACKGROUND: RESULTS:
Gd(ABE-DTTA) or Gd(DTPA) highlighted the acute infarct, whereas the four-week old infarct was visualized by Gd(DTPA), but not by Gd(ABE-DTTA). With Gd(ABE-DTTA), the mean +/- SD signal intensity enhancement (SIE) was 366 +/- 166% and 24 +/- 59% in the acute infarct and the four-week old infarct, respectively (P < 0.05). The latter did not differ significantly from signal intensity in healthy myocardium (P = NS). Gd(DTPA) produced signal intensity enhancements which were similar in acute (431 +/- 124%) and four-week old infarcts (400 +/- 124%, P = NS), and not statistically different from the Gd(ABE-DTTA)-induced SIE in acute infarct. The existence and localization of both infarcts were confirmed by triphenyltetrazolium chloride (TTC). Histologic evaluation demonstrated coagulation necrosis, inflammation, and multiple foci of calcification in the four day old infarct, while the late subacute infarct showed granulation tissue and early collagen deposition. CONCLUSIONS:
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Authors | Robert Kirschner, Levente Toth, Akos Varga-Szemes, Tamas Simor, Pal Suranyi, Pal Kiss, Balazs Ruzsics, Attila Toth, Robert Baker, Brigitta C Brott, Silvio Litovsky, Ada Elgavish, Gabriel A Elgavish |
Journal | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
(J Cardiovasc Magn Reson)
Vol. 12
Pg. 22
(Apr 07 2010)
ISSN: 1532-429X [Electronic] England |
PMID | 20377842
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Contrast Media
- Organometallic Compounds
- gadolinium N-(2-butyryloxyethyl)-N'-(2-ethyloxyethyl)-N,N'-bis(N'',N''-bis(carboxymethyl)acetamido)-1,2-ethanediamine
- Pentetic Acid
- Gadolinium DTPA
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Topics |
- Animals
- Contrast Media
- Diagnosis, Differential
- Disease Models, Animal
- Dogs
- Gadolinium DTPA
- Magnetic Resonance Imaging
(methods)
- Male
- Myocardial Infarction
(diagnosis)
- Myocardium
(pathology)
- Organometallic Compounds
- Pentetic Acid
- Predictive Value of Tests
- Time Factors
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