[Diagnosis and treatment of ocular myasthenia (author's transl)].

Abstract

After discussion of the modern concepts of pathophysiology of ocular myasthenia the ocular symptoms such as ptosis and eye muscle palsies are discussed. As important diagnostic sign the Simpson lid fatigue test before and after application of Tensilon is described. For diagnosis of myasthenic eye muscle palsies electrooculography has a special significance especially in connection with the application of Edrophonium, which normalizes myasthenic hypometric saccades and transforms them even in hypermetric saccades. In doubtful cases of eye muscle palsies the electromyogram of the affected muscle in connection with the Edrophonium-test is extremely valuable. With regard to modern treatment apart from cholinesterase inhibitors (Pyridostigmine, Neostigmine) thymectomy, the application of corticosteroids, ACTH and especially also immune suppressive drugs (Imurel etc.) is discussed. Of great significance in ocular myasthenia is the local application of cholinesterase inhibitors like Eserine, Prostigmin or Phospholine Iodide.

• Authors: A Huber
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 171 Issue 6 Pg. 889-95 (Dec 1977) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Zur Diagnose und Behandlung der okulären Myasthenie.
• PMID: 203742 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neostigmine
• Adrenocorticotropic Hormone
• Pyridostigmine Bromide

Topics

• Adrenocorticotropic Hormone (therapeutic use)
• Blepharoptosis (diagnosis)
• Diagnosis, Differential
• Eye Diseases (diagnosis, drug therapy)
• Eye Manifestations
• Humans
• Myasthenia Gravis (complications, drug therapy, physiopathology)
• Neostigmine (therapeutic use)
• Oculomotor Muscles (physiopathology)
• Pyridostigmine Bromide (therapeutic use)