Atorvastatin protects renal function in the rat with acute unilateral ureteral obstruction.

Abstract

OBJECTIVES:

To examine the effects of atorvastatin on renal hemodynamics and urinary microalbumin levels in rats with acute unilateral ureteral obstruction (UUO). Previous studies have demonstrated that treatment with statins attenuated renal structural damages in rodents with chronic UUO. However, it is not known whether statins afford protection of renal function.

METHODS:

UUO was created by ligation of the left ureter in rats maintained on a regular diet or the same diet but supplemented with atorvastatin (50 mg/kg/d) for 2 weeks. Renal clearance experiments were performed after release of UUO at 1 hour, 6 hours, or 12 hours.

RESULTS:

Atorvastatin treatment lowered plasma triglyceride but not cholesterol levels. Both glomerular filtration rate and effective renal plasma flow were significantly greater in atorvastatintreated rats after release of UUO at 1 hour, 6 hours, and 12 hours. Significant reduction of urinary microalbumin to creatinine ratios occurred in the atorvastatin-treated group at 12 hours but not earlier.

CONCLUSIONS:

Atorvastatin treatment affords protection of renal function in acute UUO and reduces urinary microalbumin levels without lowering cholesterol levels. This pleiotropic action of atorvastatin on preservation of renal hemodynamics may be important in attenuating subsequent renal structural injury in chronic UUO.

• Authors: Ciamack Kamdar, Shyan-Yih Chou, Unni M M Mooppan, Hong Kim, Frederick A Gulmi
• Journal: Urology (Urology) Vol. 75 Issue 4 Pg. 853-7 (Apr 2010) ISSN: 1527-9995 [Electronic] United States
• PMID: 20371061 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier Inc. All rights reserved.

Chemical References

• Heptanoic Acids
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Pyrroles
• Atorvastatin

Topics

• Acute Disease
• Albuminuria (prevention & control)
• Animals
• Atorvastatin
• Hemodynamics (drug effects)
• Heptanoic Acids (therapeutic use)
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Kidney (drug effects, physiopathology)
• Male
• Pyrroles (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Ureteral Obstruction (drug therapy, physiopathology)