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Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents.

Abstract
A series of bisamidines of 2,6-diaminoanthraquinone was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. A number of compounds were found to have good activity against infections in both species.
AuthorsP F Fabio, T L Fields, Y Lin, E J Burden, S Carvajal, K C Murdock, S A Lang Jr
JournalJournal of medicinal chemistry (J Med Chem) Vol. 21 Issue 3 Pg. 273-6 (Mar 1978) ISSN: 0022-2623 [Print] United States
PMID203694 (Publication Type: Journal Article)
Chemical References
  • Amebicides
  • Amidines
  • Anthraquinones
Topics
  • Amebiasis (drug therapy)
  • Amebicides (chemical synthesis)
  • Amidines (chemical synthesis, therapeutic use)
  • Animals
  • Anthraquinones (chemical synthesis, therapeutic use)
  • Cricetinae
  • Dysentery, Amebic (drug therapy)
  • Entamoeba histolytica
  • Entamoebiasis (drug therapy)
  • Female
  • Liver Abscess, Amebic (drug therapy)
  • Rats

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