[Measurement of exhaled volatile organic compounds in lung cancer patients].

Abstract

OBJECTIVE:

to study the characteristics of volatile organic compounds (VOCs) in exhaled breath of lung cancer patients, and therefore to explore its use in the diagnosis of the disease.

METHODS:

from February 2007 to September 2009, 55 patients with lung cancer, 21 patients with benign lung diseases and 30 healthy controls were enrolled in our study. The VOCs in exhaled breath were detected by the SPME (solid phase microextraction)-GC (gas chromatography) system.

RESULTS:

heptanal was detected in 45 patients of the lung cancer group, 1 of the benign lung disease group, and 1 of the healthy control group. The positive rate was higher in the lung cancer group as compared to the benign lung disease group and the healthy group combined (P < 0.05). The detection of heptanal was not related to age, smoking, histological type and staging (P > 0.05).

CONCLUSION:

heptanal maybe a useful marker in VOCs from patients with lung cancer.

• Authors: Chong-Rong Lu, Yan-Jie Hu, En-Guo Chen, Yuan-Hua Qiu, Ke-Jing Ying
• Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (Zhonghua Jie He He Hu Xi Za Zhi) Vol. 33 Issue 2 Pg. 104-8 (Feb 2010) ISSN: 1001-0939 [Print] China
• PMID: 20367949 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Volatile Organic Compounds

Topics

• Adenocarcinoma (diagnosis, physiopathology)
• Adenocarcinoma of Lung
• Breath Tests
• Case-Control Studies
• Exhalation
• Female
• Humans
• Lung Neoplasms (diagnosis, physiopathology)
• Male
• Middle Aged
• Neoplasm Staging
• Smoking
• Volatile Organic Compounds (analysis)