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Immunopotentiation of live brucellosis vaccine by adjuvants.

Abstract
In a series of studies in SPF and conventional guinea pigs, various adjuvants (larifan, polyoxidonium-PO, natrium thiosulphate-NT, TNF-β and Ribi adjuvant system-RAS) were evaluated for their ability to enhance immune responses to the live brucellosis vaccine, Brucella abortus strain 82-PS (penicillin-sensitive). Combining adjuvants with S82-PS increased synthesis of antibodies against rough (R) and smooth (S) Brucella antigens. Dynamics and levels of antibodies differed dependent upon the adjuvant. Adjuvants enhanced cell-mediated responses to S82-PS, and phagocytosis by macrophages. Humoral and cellular immune responses stimulated by the adjuvants correlated with increased vaccine protection against experimental challenge. The highest protection was demonstrated by combining TNF-β or PO with S82-PS. Our data demonstrates the potential of adjuvants to improve immunogenic properties of live brucellosis vaccines.
AuthorsAlexander A Denisov, Yulia S Korobovtseva, Olga M Karpova, Alla V Tretyakova, Larisa V Mikhina, Arkadyi V Ivanov, Konstantin M Salmakov, Roman V Borovick
JournalVaccine (Vaccine) Vol. 28 Suppl 5 Pg. F17-22 (Oct 01 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID20362624 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright © 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Adjuvants, Immunologic
  • Antibodies, Bacterial
  • Brucella Vaccine
  • Cell Wall Skeleton
  • Cord Factors
  • Lipid A
  • Lymphotoxin-alpha
  • Organic Chemicals
  • Piperazines
  • Polymers
  • Ribi adjuvant
  • larifan
  • azoximer bromide
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Animals
  • Antibodies, Bacterial (immunology)
  • Brucella Vaccine (immunology)
  • Brucella abortus (immunology)
  • Brucellosis (immunology, prevention & control)
  • Cell Proliferation
  • Cell Wall Skeleton (immunology)
  • Cord Factors (immunology)
  • Guinea Pigs
  • Immunity, Cellular
  • Immunity, Humoral
  • Lipid A (analogs & derivatives, immunology)
  • Lymphotoxin-alpha (immunology)
  • Macrophages, Peritoneal (immunology)
  • Male
  • Organic Chemicals (immunology)
  • Phagocytosis
  • Piperazines (immunology)
  • Polymers

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