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Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities.

Abstract
Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared. Although these compounds did not have specific antiplasmodial activities, some of them displayed specific in vitro activity against two cancer lines especially compound 24 with an IC(50) against the MCF7 line of 0.6 microM.
AuthorsAnge-Désiré Yapi, Nicolas Desbois, Jean-Michel Chezal, Olivier Chavignon, Jean-Claude Teulade, Alexis Valentin, Yves Blache
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 45 Issue 7 Pg. 2854-9 (Jul 2010) ISSN: 1768-3254 [Electronic] France
PMID20362359 (Publication Type: Journal Article)
CopyrightCopyright (c) 2010 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Antiprotozoal Agents
  • Aza Compounds
  • Benzophenanthridines
Topics
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Antiprotozoal Agents (chemical synthesis, chemistry, pharmacology)
  • Aza Compounds (chemistry)
  • Benzophenanthridines (chemical synthesis, chemistry, pharmacology)
  • Cell Line, Tumor
  • Drug Design
  • Humans
  • Plasmodium falciparum (drug effects)

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