Abstract | BACKGROUND AND PURPOSE: METHODS: Four groups of male Sprague-Dawley rats were studied: saline group (n=8), contrast group (n=12), heparin group (n=9), and contrast+heparin group (n=9). The middle cerebral artery was occluded for 5 hours using suture placement. Heparin was infused before suture removal and reperfusion. Saline and/or contrast were infused immediately during reperfusion. Incidence, location, and size of hemorrhage were determined by brain necropsy inspection at 24 hours. RESULTS: There was a significant increase in incidence of cortical hemorrhage from control (37.5%), contrast (75.0%), heparin (77.8%) to contrast+heparin (100%; Cochran-Mantel-Haenszel correlation, P<0.01). Both pooled contrast groups (85.7%) and pooled heparin groups (88.9%) had higher rates of cortical intracerebral hemorrhage compared with the control group (P<0.05). Similar trends for increased cortical intracerebral hemorrhage were seen in the contrast-only (P=0.18) and heparin-only (P=0.18) groups. There was a trend for decreased infarct edema in rats receiving contrast versus those without (P=0.06). CONCLUSIONS:
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Authors | Yuko Kurosawa, Aigang Lu, Pooja Khatri, Janice A Carrozzella, Joseph F Clark, Jane Khoury, Thomas A Tomsick |
Journal | Stroke
(Stroke)
Vol. 41
Issue 5
Pg. 1013-7
(May 2010)
ISSN: 1524-4628 [Electronic] United States |
PMID | 20360541
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Contrast Media
- Iodine Radioisotopes
- Iohexol
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Topics |
- Animals
- Cerebral Hemorrhage
(chemically induced, pathology)
- Contrast Media
(administration & dosage, adverse effects)
- Disease Models, Animal
- Infarction, Middle Cerebral Artery
(diagnosis, pathology)
- Injections, Intra-Arterial
- Iodine Radioisotopes
(administration & dosage, adverse effects)
- Iohexol
(administration & dosage, adverse effects)
- Male
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(diagnosis, pathology)
- Single-Blind Method
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