Effect of imexon treatment on Friend virus complex infection using genetically defined mice as a model for HIV-1 infection.

Abstract

Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune deficiency syndrome (AIDS). Intraperitoneal imexon initiated 1 or 3 days after FV inoculation and continued through 13 days after inoculation significantly reduced splenomegaly, splenic cell-free virus titers and viral RNA. Viral infectious centers/10(6) splenocytes and FV titers in the plasma were reduced, though not to a statistically significant level. The effect of imexon on survival was not statistically significant which suggested that the antiviral effects were only transiently effective. Phytohemagglutinin-induced blastogenesis and percent of total T cells, T helper cells and T suppressor/cytotoxic cells in the spleens were increased, and the percentage of B cells decreased by imexon treatment of both FV-infected and uninfected mice. The splenic natural killer cell activity and interleukin-1 production were not markedly affected. Virus specific neutralizing antibody developed in both imexon- and placebo-treated FV-infected mice, although titers were lower in the imexon-treated animals.

• Authors: J D Morrey, R P Warren, K M Okleberry, R A Burger, M A Chirigos, R W Sidwell
• Journal: Antiviral research (Antiviral Res) Vol. 15 Issue 1 Pg. 51-65 (Jan 1991) ISSN: 0166-3542 [Print] Netherlands
• PMID: 2036000 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Antiviral Agents
• Hexanones
• Phytohemagglutinins
• RNA, Viral
• 4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one

Topics

• Acquired Immunodeficiency Syndrome (drug therapy)
• Animals
• Antineoplastic Agents (pharmacology)
• Antiviral Agents (pharmacology)
• Cell Count
• Female
• Friend murine leukemia virus (drug effects, genetics)
• HIV-1 (drug effects, genetics)
• Hexanones (pharmacology)
• Leukemia, Experimental (drug therapy, microbiology)
• Lymphocytes (drug effects, microbiology)
• Male
• Mice
• Mice, Inbred Strains
• Models, Genetic
• Phytohemagglutinins (pharmacology)
• RNA, Viral (analysis)
• Splenomegaly (drug therapy, microbiology)