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Folate conjugated poly(ester amine) for lung cancer therapy.

Abstract
Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.
AuthorsRohidas B Arote, Mi-Kyong Yoon, Tae-Hee Kim, Dhananjay Jere, Hu-Lin Jiang, You-Kyoung Kim, In-Kyu Park, Chong-Su Cho
JournalJournal of nanoscience and nanotechnology (J Nanosci Nanotechnol) Vol. 10 Issue 5 Pg. 3294-8 (May 2010) ISSN: 1533-4880 [Print] United States
PMID20358942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Macromolecular Substances
  • Nanocapsules
  • Polyesters
  • polycaprolactone
  • Folic Acid
Topics
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Folic Acid (administration & dosage, chemistry)
  • Humans
  • Lung Neoplasms (drug therapy, pathology)
  • Macromolecular Substances (chemistry)
  • Materials Testing
  • Molecular Conformation
  • Nanocapsules (chemistry, ultrastructure)
  • Nanomedicine (methods)
  • Polyesters (chemistry)
  • Surface Properties

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