Abstract |
Feeding broccoli sprout extracts providing daily doses of 10 micromol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
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Authors | Albena T Dinkova-Kostova, Jed W Fahey, Andrea L Benedict, Stephanie N Jenkins, Lingxiang Ye, Scott L Wehage, Paul Talalay |
Journal | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
(Photochem Photobiol Sci)
Vol. 9
Issue 4
Pg. 597-600
(Apr 2010)
ISSN: 1474-9092 [Electronic] England |
PMID | 20354656
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Carbohydrates
- Glucosinolates
- Imidoesters
- Oximes
- Plant Extracts
- Sulfoxides
- glucoraphanin
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Topics |
- Animals
- Brassica
(chemistry, metabolism)
- Dietary Carbohydrates
(metabolism)
- Female
- Glucosinolates
(metabolism)
- Imidoesters
(metabolism)
- Mice
- Mice, Hairless
- Neoplasms, Radiation-Induced
(pathology, prevention & control)
- Oximes
- Plant Extracts
(pharmacology)
- Risk
- Skin Neoplasms
(pathology, prevention & control)
- Sulfoxides
- Time Factors
- Ultraviolet Rays
(adverse effects)
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