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Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

Abstract
Feeding broccoli sprout extracts providing daily doses of 10 micromol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
AuthorsAlbena T Dinkova-Kostova, Jed W Fahey, Andrea L Benedict, Stephanie N Jenkins, Lingxiang Ye, Scott L Wehage, Paul Talalay
JournalPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (Photochem Photobiol Sci) Vol. 9 Issue 4 Pg. 597-600 (Apr 2010) ISSN: 1474-9092 [Electronic] England
PMID20354656 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Dietary Carbohydrates
  • Glucosinolates
  • Imidoesters
  • Oximes
  • Plant Extracts
  • Sulfoxides
  • glucoraphanin
Topics
  • Animals
  • Brassica (chemistry, metabolism)
  • Dietary Carbohydrates (metabolism)
  • Female
  • Glucosinolates (metabolism)
  • Imidoesters (metabolism)
  • Mice
  • Mice, Hairless
  • Neoplasms, Radiation-Induced (pathology, prevention & control)
  • Oximes
  • Plant Extracts (pharmacology)
  • Risk
  • Skin Neoplasms (pathology, prevention & control)
  • Sulfoxides
  • Time Factors
  • Ultraviolet Rays (adverse effects)

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