Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet.

Abstract

High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg(-1) bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity.

• Authors: V A Gault, W D Porter, P R Flatt, C Hölscher
• Journal: International journal of obesity (2005) (Int J Obes (Lond)) Vol. 34 Issue 8 Pg. 1341-4 (Aug 2010) ISSN: 1476-5497 [Electronic] England
• PMID: 20351729 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fats
• Peptides
• Venoms
• Exenatide

Topics

• Animals
• Cognition Disorders (drug therapy, physiopathology)
• Dietary Fats (administration & dosage)
• Exenatide
• Hippocampus (drug effects, physiopathology)
• Male
• Mice
• Neuronal Plasticity (drug effects, physiology)
• Peptides (pharmacology)
• Venoms (pharmacology)