Improved signs, symptoms, and quality of life associated with dry eye syndrome: hydroxypropyl cellulose ophthalmic insert patient registry.

Abstract

OBJECTIVES:

To evaluate the acceptability, ease of use, and efficacy of hydroxypropyl cellulose ophthalmic inserts in reducing signs and symptoms of moderate-to-severe dry eye syndrome (DES), and improving quality of life (QoL) and activities of daily living (ADL).

METHODS:

The multicenter, prospective, open-label, 4-week registry comprised 520 patients with bilateral DES and a history of artificial tear use, or a desire to use artificial tears within the previous week. Visit 1 encompassed a clinical evaluation and symptom and QoL questionnaires, including the Ocular Surface Disease Index. Patients were trained to use inserts, which were used once daily, thereafter, as monotherapy or with existing therapy. At visit 2, clinical evaluation and questionnaires evaluated changes in signs, symptoms, ADL, and QoL. Adverse events were monitored throughout the registry.

RESULTS:

There were 418 (80.4%) completers. Statistically significant improvements in discomfort, burning, dryness, grittiness, stinging, and light sensitivity, as well as clinical signs of keratitis, conjunctival staining, and tear volume were seen (P<0.05). Mean Ocular Surface Disease Index total scores improved by 21.3% (P<0.05). Blurred vision, affecting 8.7% of patients, was the most commonly reported adverse event leading to discontinuation.

CONCLUSIONS:

Hydroxypropyl cellulose ophthalmic inserts significantly improved signs and symptoms of moderate-to-severe DES, as well as ADL and QoL. Benefits were additive to those seen with patients' existing care.

• Authors: Bruce H Koffler, Marguerite McDonald, Donald S Nelinson, LAC-07-01 Study Group
• Journal: Eye & contact lens (Eye Contact Lens) Vol. 36 Issue 3 Pg. 170-6 (May 2010) ISSN: 1542-233X [Electronic] United States
• PMID: 20351555 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Cellulose
• hydroxypropylcellulose

Topics

• Adolescent
• Adult
• Aged
• Cellulose (administration & dosage, adverse effects, analogs & derivatives)
• Drug Delivery Systems
• Dry Eye Syndromes (drug therapy, pathology, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Patients
• Prospective Studies
• Quality of Life
• Registries
• Treatment Outcome
• Vision Disorders (chemically induced)
• Young Adult