Abstract | OBJECTIVES: METHODS: We prospectively studied 291 joints (134 hips and 157 knees) in 106 SLE patients without osteonecrosis after initial corticosteroid therapy, with a mean follow-up period of 13.6 years and a follow-up rate of 71%. All patients had undergone periodic MRI examination of the hip and knee joints for >10 years. RESULTS: New osteonecrosis developed in 6 joints (3%) and only occurred after SLE recurrence in association with increased corticosteroid doses (to>30 mg/day [p=0.008]). New lesions were delayed for a mean 5.9 years after initial corticosteroid administration. The mean time from SLE recurrence to appearance of new lesions was 6.2 months. SLE recurrence occurred in 131 joints (45%), while SLE was well controlled in 160 joints (55%). CONCLUSIONS:
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Authors | J Nakamura, S Ohtori, M Sakamoto, A Chuma, I Abe, K Shimizu |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2010 Jan-Feb
Vol. 28
Issue 1
Pg. 13-8
ISSN: 0392-856X [Print] Italy |
PMID | 20346232
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, adverse effects)
- Adult
- Female
- Follow-Up Studies
- Hip Joint
(pathology)
- Humans
- Incidence
- Lupus Erythematosus, Systemic
(drug therapy, epidemiology)
- Magnetic Resonance Imaging
- Middle Aged
- Osteonecrosis
(chemically induced, epidemiology, pathology)
- Recurrence
- Risk Factors
- Time Factors
- Young Adult
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