Benzophenones and biflavonoids from Garcinia livingstonei fruits.

Abstract

A series of 13 known compounds, including seven benzophenones [guttiferone A (1), guttiferone K (2), xanthochymol (3), guttiferone E (4), cycloxanthochymol (5), isoxanthochymol (6), and gambogenone (7)], five biflavonoids [amentoflavone (8), 3,8''-biapigenin (9), (+)-volkensiflavone (10), (+)-morelloflavone (11), and (+)-fukugiside (12)], and the xanthone derivative alloathyriol (13), were identified from the fruits of Garcinia livingstonei (Clusiaceae). This is the first time that compounds 2-7, 9, 12, and 13 have been reported in this species. The cytotoxicity of benzophenones 1 and 2 was assessed for their effect on HCT-116, HT-29, and SW-480 human colon cancer cell lines. Both compounds exhibited strong activity against HCT-116 and HT-29 cell lines with IC(50) values between 5 and 10 microM, and somewhat weaker activity with SW-480 cells (IC(50) values ranging from 18 to 25 microM).

• Authors: Hui Yang, Mario Figueroa, Satoshi To, Scott Baggett, Bei Jiang, Margaret J Basile, I Bernard Weinstein, Edward J Kennelly
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 58 Issue 8 Pg. 4749-55 (Apr 28 2010) ISSN: 1520-5118 [Electronic] United States
• PMID: 20345100 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Benzophenones
• Biflavonoids

Topics

• Benzophenones (isolation & purification)
• Biflavonoids (isolation & purification)
• Cell Line
• Garcinia (chemistry)
• Humans