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Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study.

Abstract
A case of solitary fibrous tumor (SFT) arising in the soft tissue of the left inguinal region is reported. A 57-year-old Japanese woman presented with a nonadherent, well-defined, oval mass that was 2 x 3 cm in diameter and located in the inguinal soft tissue. Microscopic evaluation showed proliferation of spindle-shaped, fibroblast-like cells by the coexistence of hypo- and hypercellular areas with mast cell infiltration separated by hemangiopericytoma-like blood vessels. Immunohistochemistry revealed strong expression of CD34 and CD99 in the fibroblast-like cells, supporting the diagnosis of SFT. Although the patient was free of symptoms such as hypoglycemia, immunoreactive insulin-like growth factor (IGF)-II was localized in the socalled Golgi area of the spindle-shaped cells. In conclusion, immunoreactive IGF-II was detected in SFT that was not associated with hypoglycemia.
AuthorsTakashi Yuri, Sayaka Kanematsu, Yen-Chang Lei, Maki Kuwata, Masaharu Oishi, Airo Tsubura
JournalMedical molecular morphology (Med Mol Morphol) Vol. 43 Issue 1 Pg. 60-4 (Mar 2010) ISSN: 1860-1499 [Electronic] Japan
PMID20340008 (Publication Type: Case Reports, Journal Article)
Chemical References
  • 12E7 Antigen
  • Antigens, CD
  • Antigens, CD34
  • CD99 protein, human
  • Cell Adhesion Molecules
  • Insulin-Like Growth Factor II
Topics
  • 12E7 Antigen
  • Abdominal Neoplasms (chemistry, diagnosis, surgery)
  • Antigens, CD (analysis)
  • Antigens, CD34 (analysis)
  • Cell Adhesion Molecules (analysis)
  • Female
  • Golgi Apparatus (chemistry)
  • Humans
  • Hypoglycemia (metabolism)
  • Immunohistochemistry
  • Inguinal Canal
  • Insulin-Like Growth Factor II (analysis)
  • Middle Aged
  • Solitary Fibrous Tumors (chemistry, diagnosis, surgery)

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