Human leucocyte antigen class I and class II antigen expression in malignant fibrous histiocytoma, fibrosarcoma and dermatofibrosarcoma protuberans is significantly downregulated.

Abstract

BACKGROUND:

Abnormalities in the expression of human leucocyte antigens (HLA) by tumour cells impair cellular immune responses promoting immune evasion and tumour survival. To date, studies analysing HLA class I and class II expression levels in malignant fibrous histiocytomas, fibrosarcomas and dermatofibrosarcoma protuberans are limited.

AIMS:

Therefore, we investigated the in vivo expression profile of HLA class I and class II antigens in 99 malignant fibrous histiocytomas, 20 fibrosarcomas and 34 dermatofibrosarcoma protuberans from different anatomical sites.

MATERIAL AND METHODS:

Immunohistochemistry using monoclonal antibodies to HLA class I and class II antigens was used to define the expression levels of these antigens on respective tumour samples.

RESULTS:

Frequent loss or downregulation of HLA class I and class II expression in malignant fibrous tumours was observed for the different types of tumours examined.

DISCUSSION:

The data presented suggest for the first time a high frequency of HLA class I and class II abnormalities in malignant fibrous histiocytomas, fibrosarcomas and dermatofibrosarcoma protuberans in vivo.

CONCLUSION:

This information might be useful in the practical and clinical design of tumour vaccination strategies.

• Authors: M Meissner, V König, I Hrgovic, E Valesky, R Kaufmann
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 24 Issue 11 Pg. 1326-32 (Nov 2010) ISSN: 1468-3083 [Electronic] England
• PMID: 20337820 (Publication Type: Journal Article)
• Copyright: © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

Chemical References

• Histocompatibility Antigens Class I
• Histocompatibility Antigens Class II

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antigen Presentation (immunology)
• Child
• Child, Preschool
• Dermatofibrosarcoma (immunology, metabolism, pathology)
• Down-Regulation (immunology)
• Female
• Histiocytoma, Malignant Fibrous (immunology, metabolism, pathology)
• Histocompatibility Antigens Class I (metabolism)
• Histocompatibility Antigens Class II (metabolism)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Prognosis
• Skin Neoplasms (immunology, metabolism, pathology)
• Tumor Escape (immunology)
• Young Adult