Abstract | BACKGROUND: OBJECTIVE: METHODS: Balb/c mice were sensitized and challenged acutely or chronically to ovalbumin (OVA). The impact of tiotropium bromide was assessed using these mice models by histologic, morphometric, and molecular techniques. Moreover, the effect of tiotropium bromide on Th2 cytokine production from purified human peripheral blood mononuclear cells (PBMCs) was assessed. RESULTS: CONCLUSION:
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Authors | S Ohta, N Oda, T Yokoe, A Tanaka, Y Yamamoto, Y Watanabe, K Minoguchi, T Ohnishi, T Hirose, H Nagase, K Ohta, M Adachi |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 40
Issue 8
Pg. 1266-75
(Aug 2010)
ISSN: 1365-2222 [Electronic] England |
PMID | 20337647
(Publication Type: Journal Article)
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Chemical References |
- Bronchodilator Agents
- Cytokines
- Scopolamine Derivatives
- Tiotropium Bromide
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Topics |
- Airway Remodeling
(drug effects)
- Animals
- Asthma
(drug therapy, immunology, pathology)
- Bronchoalveolar Lavage Fluid
(cytology, immunology)
- Bronchodilator Agents
(therapeutic use)
- Cytokines
(biosynthesis, drug effects)
- Disease Models, Animal
- Female
- Humans
- Leukocytes, Mononuclear
(drug effects, immunology, metabolism)
- Mice
- Mice, Inbred BALB C
- Pneumonia
(drug therapy, pathology)
- Scopolamine Derivatives
(therapeutic use)
- Th2 Cells
(drug effects, immunology, metabolism)
- Tiotropium Bromide
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