Abstract | OBJECTIVE: METHODS: The expression of 14-3-3 sigma and HSP27 was detected by immunohistochemical staining in 50 pathologically verified CRC cases. The association of clinical data with 14-3-3 sigma and HSP27 expression was examined. RESULTS: The positive expression rate of 14-3-3 sigma was 10% in normal control mucosa and 58% in CRC tissue (P<0.01). The positive expression rate of HSP27 was 16% in normal control mucosa and 54% in CRC tissue (P<0.01). No correlation between 14-3-3 sigma and HSP27 expression was found in CRC tissue (P>0.05). The expression of 14-3-3 sigma was associated with patient age, tumor diameter and lymph node metastasis (LNM) (P<0.05), but not with gender, tumor differentiation or serous membrane invasion (P>0.05). The expression of HSP27 was associated with LNM (P<0.05), but not with gender, age, differentiation, tumor diameter or serous membrane invasion (P>0.05). CONCLUSION: The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with LNM in CRC.
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Authors | Hai-ping Pei, Hua Ge, Rui Jiang, Hong Zhu |
Journal | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
(Zhonghua Wei Chang Wai Ke Za Zhi)
Vol. 13
Issue 3
Pg. 213-5
(Mar 2010)
ISSN: 1671-0274 [Print] China |
PMID | 20336542
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 14-3-3 Proteins
- Biomarkers, Tumor
- HSP27 Heat-Shock Proteins
- Neoplasm Proteins
- Exonucleases
- Exoribonucleases
- SFN protein, human
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Topics |
- 14-3-3 Proteins
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Colorectal Neoplasms
(metabolism, pathology)
- Exonucleases
(metabolism)
- Exoribonucleases
- Female
- HSP27 Heat-Shock Proteins
(metabolism)
- Humans
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Proteins
(metabolism)
- Young Adult
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