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[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer].

AbstractOBJECTIVE:
To investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance.
METHODS:
The expression of 14-3-3 sigma and HSP27 was detected by immunohistochemical staining in 50 pathologically verified CRC cases. The association of clinical data with 14-3-3 sigma and HSP27 expression was examined.
RESULTS:
The positive expression rate of 14-3-3 sigma was 10% in normal control mucosa and 58% in CRC tissue (P<0.01). The positive expression rate of HSP27 was 16% in normal control mucosa and 54% in CRC tissue (P<0.01). No correlation between 14-3-3 sigma and HSP27 expression was found in CRC tissue (P>0.05). The expression of 14-3-3 sigma was associated with patient age, tumor diameter and lymph node metastasis (LNM) (P<0.05), but not with gender, tumor differentiation or serous membrane invasion (P>0.05). The expression of HSP27 was associated with LNM (P<0.05), but not with gender, age, differentiation, tumor diameter or serous membrane invasion (P>0.05).
CONCLUSION:
The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with LNM in CRC.
AuthorsHai-ping Pei, Hua Ge, Rui Jiang, Hong Zhu
JournalZhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery (Zhonghua Wei Chang Wai Ke Za Zhi) Vol. 13 Issue 3 Pg. 213-5 (Mar 2010) ISSN: 1671-0274 [Print] China
PMID20336542 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 14-3-3 Proteins
  • Biomarkers, Tumor
  • HSP27 Heat-Shock Proteins
  • Neoplasm Proteins
  • Exonucleases
  • Exoribonucleases
  • SFN protein, human
Topics
  • 14-3-3 Proteins
  • Adult
  • Aged
  • Biomarkers, Tumor (metabolism)
  • Colorectal Neoplasms (metabolism, pathology)
  • Exonucleases (metabolism)
  • Exoribonucleases
  • Female
  • HSP27 Heat-Shock Proteins (metabolism)
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Proteins (metabolism)
  • Young Adult

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