Diode laser hair removal does not interfere with botulinum toxin A treatment against axillary hyperhidrosis.

Abstract

BACKGROUND AND OBJECTIVE:

The possible interference of combined laser hair removal and Botulinum toxin A (BoNT/A) injections in the treatment of axillary hyperhidrosis has not previously been explored. In order to examine this potential interference, we assessed the effect of BoNT/A on axillary hyperhidrosis with and without concomitant diode laser axillary hair removal.

STUDY DESIGN/MATERIALS AND METHODS:

In a prospective, double blind, randomized cross over trial, nine patients suffering from primary axillary hyperhidrosis were laser-treated on one randomly assigned axilla. One week later, both axillas were injected intradermally with BoNT/A (100 MU per axilla). During the same session, the previously untreated axilla was lasered. Axillary sweat rates (in g/5 minutes.) were determined by gravimetry and compared at rest, during mental exercise, and during physical exercise. Additionally, subjective outcome measures were assessed by a visual analogue scale, Dermatology Life Quality Index, and Global Clinical Impression score.

RESULTS:

No differences were found regarding the effect of BoNT/A on previously laser-treated and laser co-treated sides over time course for any of the outcome parameters. Sweat production was reduced 3 weeks after BoNT/A treatment by 93.5% at rest, 96.5% during mental exercise, and 67% during physical exercise.

CONCLUSIONS:

Concomitant laser hair removal does not interfere with BoNT/A treatment on axillary hyperhidrosis.

• Authors: Anna Paul, Gottfried Kranz, Andreas Schindl, Georg S Kranz, Eduard Auff, Thomas Sycha
• Journal: Lasers in surgery and medicine (Lasers Surg Med) Vol. 42 Issue 3 Pg. 211-4 (Mar 2010) ISSN: 1096-9101 [Electronic] United States
• PMID: 20333738 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Botulinum Toxins, Type A

Topics

• Adult
• Analysis of Variance
• Axilla
• Botulinum Toxins, Type A (therapeutic use)
• Combined Modality Therapy
• Cross-Over Studies
• Double-Blind Method
• Female
• Follow-Up Studies
• Hair Removal (methods)
• Humans
• Hyperhidrosis (diagnosis, therapy)
• Injections, Intradermal
• Lasers, Semiconductor (therapeutic use)
• Prospective Studies
• Quality of Life
• Risk Assessment
• Severity of Illness Index
• Treatment Outcome
• Young Adult