Hypertrophic cervical elongation: clinical and histological correlations.

Abstract

INTRODUCTION AND HYPOTHESIS:

The objective of this study is to define the diagnosis of hypertrophic cervical elongation clinically and to perform histochemical and histological evaluations of patients with and without hypertrophic cervical elongation.

METHODS:

This prospective study was conducted at Louisiana State University between December 2005 and May 2008. Fourteen women with cervical elongation and 28 women without prolapse were studied.

RESULTS:

The amounts of elastin, collagen, and smooth muscle did not differ between study and control groups. Estrogen and progesterone receptor content in cervical elongation were elevated compared to the cervix of women without prolapse. Hypertrophic cervical elongation was defined as the difference between point C and point D of the Pelvic Organ Prolapse Quantification system greater than 8 cm.

CONCLUSIONS:

Estrogen and progesterone receptor levels are greater in women with hypertrophic cervical elongation compared with a normal cervix.

• Authors: Okechukwu A Ibeanu, Ralph R Chesson, Dane Sandquist, Javier Perez, Kerri Santiago, Thomas E Nolan
• Journal: International urogynecology journal (Int Urogynecol J) Vol. 21 Issue 8 Pg. 995-1000 (Aug 2010) ISSN: 1433-3023 [Electronic] England
• PMID: 20333504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone
• Collagen
• Elastin

Topics

• Adult
• Case-Control Studies
• Cervix Uteri (metabolism, pathology)
• Collagen (metabolism)
• Elastin (metabolism)
• Female
• Humans
• Hypertrophy (diagnosis, metabolism, pathology)
• Middle Aged
• Pelvic Organ Prolapse (diagnosis, metabolism, pathology)
• Pilot Projects
• Prospective Studies
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Retrospective Studies