ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells.

Abstract	AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified: ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymerase chain reaction, immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy. Our results show that ATAD3A is the major form expressed in LADC. Silencing of ATAD3A expression increased mitochondrial fragmentation and cisplatin sensitivity. Serum deprivation increased ATAD3A expression and drug resistance. These results suggest that ATAD3A could be an anti-apoptotic marker in LADC.
Authors	Hsin-Yuan Fang, Chia-Ling Chang, Shu-Han Hsu, Chih-Yang Huang, Shu-Fen Chiang, Shiow-Her Chiou, Chun-Hua Huang, Yi-Ting Hsiao, Tze-Yi Lin, I-Ping Chiang, Wen-Hu Hsu, Sumio Sugano, Chih-Yi Chen, Ching-Yuang Lin, Wen-Je Ko, Kuan-Chih Chow
Journal	Journal of cell science (J Cell Sci) Vol. 123 Issue Pt 7 Pg. 1171-80 (Apr 01 2010) ISSN: 1477-9137 [Electronic] England
PMID	20332122 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	ATAD3A protein, human Apoptosis Regulatory Proteins Membrane Proteins Mitochondrial Proteins RNA, Small Interfering Adenosine Triphosphatases ATPases Associated with Diverse Cellular Activities Cisplatin
Topics	ATPases Associated with Diverse Cellular Activities Adenocarcinoma (drug therapy, genetics, metabolism, pathology) Adenosine Triphosphatases (genetics, metabolism) Apoptosis (drug effects, genetics) Apoptosis Regulatory Proteins (genetics, metabolism) Cisplatin (pharmacology) Disease Progression Drug Resistance (genetics) Female HeLa Cells Humans Immunohistochemistry Lung Neoplasms (drug therapy, genetics, metabolism, pathology) Male Membrane Proteins (genetics, metabolism) Microscopy, Fluorescence Mitochondria (drug effects, genetics, ultrastructure) Mitochondrial Proteins (genetics, metabolism) Neoplasm Staging RNA, Small Interfering (genetics) Sequence Analysis, DNA

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