[Antiviral activity of several nucleic acid components methylated in the N-position].

Abstract

The degree of reproducation of Rous sarcoma, mumps, and vaccinia viruses in chick embryo cell culture incubated in the presence of 9-methyladenine was considerably lower than reproducation of these viruses in the cells propagated without this substance. 1-methyluracil and 1-methylthymine reduced considerably the amount of Rous sarcoma virus produced by the cells as compared to the controls. The presence of these substances in the maintenance medium does not prevent virus infection of the cells, and their effect appears to be associated with nonspecific action on the late stages of the virus reproduction.

• Authors: A I Kolosov, O M Voronova, O K Kuznetsov
• Journal: Voprosy virusologii (Vopr Virusol) 1977 Nov-Dec Issue 6 Pg. 739-42 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Protivovirusnaia aktivnost' nekotorykh metilirovannykh v N-polozhenii komponentov nukleinovykh kislot.
• PMID: 203117 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Uracil
• Adenine
• Thymine

Topics

• Adenine (analogs & derivatives)
• Antiviral Agents
• Avian Sarcoma Viruses (drug effects)
• Cell Line
• Depression, Chemical
• Mumps virus (drug effects)
• Thymine (analogs & derivatives)
• Uracil (analogs & derivatives)
• Variola virus (drug effects)
• Virus Replication (drug effects)