Abstract |
Myeloid leukemia cells of human and murine origin can be induced to differentiate into more mature forms which lose their neoplastic properties. The hormonal form of vitamin D is a powerful inducer of monocytic differentiation, but its therapeutic use is limited by hypercalcemia. It was recently reported that a novel derivative of vitamin D, 1,25-dihydroxy-16-ene-23-yne-vitamin D3, is an exceptionally potent inducer of monocytic differentiation, and prolongs survival of mice bearing leukemia cells. We now show that this compound is also a most potent inhibitor of erythrodifferentiation. This finding has important implications for the control of hematopoiesis.
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Authors | S S Kolla, D C Moore, G P Studzinski |
Journal | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
(Proc Soc Exp Biol Med)
Vol. 197
Issue 2
Pg. 214-7
(Jun 1991)
ISSN: 0037-9727 [Print] United States |
PMID | 2031057
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Vitamin D
- Calcitriol
- Ro 23-7553
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Topics |
- Calcitriol
(analogs & derivatives, pharmacology)
- Cell Differentiation
(drug effects)
- Cell Line
- Erythrocytes
(cytology, drug effects)
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Monocytes
(cytology, drug effects)
- Tumor Cells, Cultured
- Vitamin D
(analogs & derivatives)
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