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Antitumor activity of quassinoids from Hannoa klaineana.

Abstract
Of the five quassinoids isolated from the root bark of Hannoa klaineana, only 15-desacetylundulatone was found active against P388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma. Undulatone and especially 15-O-beta-D-glucopyranosyl-21-hydroxy-glaucarubolone were found to be more toxic while 6 alpha-tigloyloxy-glaucarubol and 21-hydroxyglaucarubolone were found inactive. Structure-activity relationships are discussed.
AuthorsL Lumonadio, G Atassi, M Vanhaelen, R Vanhaelen-Fastre
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 31 Issue 1 Pg. 59-65 (Jan 1991) ISSN: 0378-8741 [Print] Ireland
PMID2030594 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
Topics
  • Adenocarcinoma (drug therapy)
  • Animals
  • Antineoplastic Agents, Phytogenic (isolation & purification, therapeutic use)
  • Drug Screening Assays, Antitumor
  • Leukemia P388 (drug therapy)
  • Melanoma, Experimental (drug therapy)
  • Mice
  • Plant Extracts (isolation & purification, therapeutic use)
  • Structure-Activity Relationship

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