Abstract |
Of the five quassinoids isolated from the root bark of Hannoa klaineana, only 15-desacetylundulatone was found active against P388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma. Undulatone and especially 15-O-beta-D-glucopyranosyl-21-hydroxy-glaucarubolone were found to be more toxic while 6 alpha-tigloyloxy-glaucarubol and 21-hydroxyglaucarubolone were found inactive. Structure-activity relationships are discussed.
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Authors | L Lumonadio, G Atassi, M Vanhaelen, R Vanhaelen-Fastre |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 31
Issue 1
Pg. 59-65
(Jan 1991)
ISSN: 0378-8741 [Print] Ireland |
PMID | 2030594
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Plant Extracts
|
Topics |
- Adenocarcinoma
(drug therapy)
- Animals
- Antineoplastic Agents, Phytogenic
(isolation & purification, therapeutic use)
- Drug Screening Assays, Antitumor
- Leukemia P388
(drug therapy)
- Melanoma, Experimental
(drug therapy)
- Mice
- Plant Extracts
(isolation & purification, therapeutic use)
- Structure-Activity Relationship
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