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[Dopamine D4 receptor hypoxia sensitivity and child psychiatric disorders].

Abstract
Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent child psychiatric problems with a complex genetic and environmental background. According to the prevailing view, main factors of the disorder are prefrontal dopamine deficiency and incomplete central dopaminergic functioning. Twin studies suggest substantial heritability in the background of the disease, and the studied candidate genes involve components of the dopamine system. Moreover, various noxious pre- and perinatal environmental impacts have been implicated in the pathogenesis of ADHD. Here we review experimental results from epidemiological, tissue and animal studies that assigned a causal role to fetal hypoxia in the development of ADHD and pointed out that the dopaminergic neurotransmission is sensitive to hypoxia. Allelic variants of the D4 dopamine receptor (DRD4) are well characterized risk factors of ADHD. Recently we have reported that hypoxia enhanced the promoter activity of DRD4 gene several fold. These observations suggest that the effect of hypoxia on the dopaminergic neurotransmission might be an important factor in the pathomechanism of ADHD.
AuthorsViktor Mózes, Melinda Bence, Mária Sasvári-Székely, Gergely Keszler
JournalNeuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology (Neuropsychopharmacol Hung) Vol. 12 Issue 1 Pg. 289-93 (Mar 2010) ISSN: 1419-8711 [Print] Hungary
Vernacular TitleA dopamin D4-es receptor hipoxia érzékenységének gyermekpszichiátriai vonatkozásai.
PMID20305304 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Drd4 protein, rat
  • Receptors, Dopamine D4
  • Dopamine
Topics
  • Animals
  • Attention Deficit Disorder with Hyperactivity (etiology, genetics, metabolism)
  • Child
  • Disease Models, Animal
  • Dopamine (metabolism)
  • Fetal Hypoxia (complications, metabolism)
  • Gene Frequency
  • Humans
  • Promoter Regions, Genetic
  • Receptors, Dopamine D4 (genetics, metabolism)
  • Risk Factors
  • Synaptic Transmission
  • Twin Studies as Topic

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