Cardiovascular effects of nonivamide succinate.

Abstract

Intravenous injection of nonivamide or nonivamide succinate (25, 250 nmol/kg) into Wistar rats induced bradycardia, hypotension, apnea and a triphasic blood pressure response: an initial short fall (effect A), an intermediate rise (effect B), and a subsequent delayed fall (effect C) of blood pressure. This blood pressure response remained unchanged after treatment with propranolol or phentolamine. In atropine-pretreatment rats the initial effect A was markedly decreased and effect C was slight increased. Effect A was absent after bilateral vagotomy. Unilateral microinjection of nonivamide succinate (3, 30 fmol) into the nucleus tractus solitarii produced a marked reduction in blood pressure and heart rate. In the isolated aorta of the guinea pig, application of either nonivamide or its succinate (10(-8) to 10(-5) M) eliminated the smooth muscle tone produced by phenylephrine (10(-6) M). Re-exposure to these agents, however, produced an immediate tachyphylactic relaxing response and prolonged rebound contractile response. Both compounds induced a vascular contraction rather than relaxation during tachyphylaxis. The potency of nonivamide succinate was found to be slightly greater than that of nonivamide.

• Authors: J L Yeh, I J Chen
• Journal: Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences (Gaoxiong Yi Xue Ke Xue Za Zhi) Vol. 7 Issue 4 Pg. 173-82 (Apr 1991) ISSN: 0257-5655 [Print] China (Republic : 1949- )
• PMID: 2030524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vasodilator Agents
• Vanillic Acid
• Capsaicin
• nonivamide

Topics

• Animals
• Blood Pressure (drug effects)
• Capsaicin (analogs & derivatives)
• Depression, Chemical
• Guinea Pigs
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Male
• Rats
• Rats, Inbred Strains
• Vanillic Acid (analogs & derivatives, pharmacology)
• Vasodilation (drug effects)
• Vasodilator Agents