Booster vaccination after neonatal priming with acellular pertussis vaccine.

Abstract

After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.

• Authors: Markus Knuf, Heinz-Josef Schmitt, Jeanne-Marie Jacquet, Alix Collard, Dorothee Kieninger, Claudius U Meyer, Claire-Anne Siegrist, Fred Zepp
• Journal: The Journal of pediatrics (J Pediatr) Vol. 156 Issue 4 Pg. 675-8 (Apr 2010) ISSN: 1097-6833 [Electronic] United States
• PMID: 20303444 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Mosby, Inc. All rights reserved.

Chemical References

• Pertussis Vaccine
• Vaccines, Acellular

Topics

• Dose-Response Relationship, Drug
• Follow-Up Studies
• Humans
• Immunization, Secondary (methods)
• Infant
• Infant, Newborn
• Pertussis Vaccine (administration & dosage)
• Prognosis
• Vaccination (methods)
• Vaccines, Acellular
• Whooping Cough (prevention & control)