Abstract | PURPOSE: Traditional treatment for advanced penile verrucous carcinoma is penectomy. This mostly leads to remarkable psychosexual problems and greatly affects quality of life, especially in young patients. To preserve the penis we used intra-aortic infusion chemotherapy for advanced verrucous carcinoma. MATERIALS AND METHODS: RESULTS:
After treatment 4 patients achieved a complete response and were disease-free 3 years 9 months to 17 years 10 months (median 11 years 3 months) after therapy. Two patients had a partial response. The patient with a shaft tumor subsequently underwent total penectomy due to unbearable penile pain 4 years after infusion with various drugs without an appreciable response. He has survived 12 years 5 months after initial treatment. The other patient with glans and prepuce tumors had progression with bilateral inguinal metastases despite 1 1/2 years of infusion therapy. Total penectomy was done. Histological examination of the glans mass revealed moderately differentiated squamous cell carcinoma. Patient condition progressed rapidly and he died 11 months after penectomy. CONCLUSIONS:
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Authors | Maw-Chang Sheen, Hamm-Ming Sheu, Mei-Yu Jang, Chee-Yin Chai, Yi-Wen Wang, Chih-Fung Wu |
Journal | The Journal of urology
(J Urol)
Vol. 183
Issue 5
Pg. 1830-5
(May 2010)
ISSN: 1527-3792 [Electronic] United States |
PMID | 20303107
(Publication Type: Journal Article)
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Copyright | 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antimetabolites, Antineoplastic
- Vitamin B Complex
- Mitomycin
- Leucovorin
- Fluorouracil
- Methotrexate
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Topics |
- Adult
- Aged
- Antimetabolites, Antineoplastic
(administration & dosage)
- Aorta, Abdominal
- Carcinoma, Verrucous
(drug therapy)
- Fluorouracil
(administration & dosage)
- Humans
- Infusions, Intra-Arterial
(methods)
- Leucovorin
(administration & dosage)
- Male
- Methotrexate
(administration & dosage)
- Middle Aged
- Mitomycin
(administration & dosage)
- Penile Neoplasms
(drug therapy)
- Treatment Outcome
- Vitamin B Complex
(administration & dosage)
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