Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats.

Abstract

The effect of 2,2-dichlorovinyl dimethyl phosphate on redox homeostasis in male rats was investigated. Rats were grouped into four: A, B, C and D where A (the control) received orally 1 ml of distilled water; B, C and D (test groups) received orally 2.5, 5 and 10mg/kg body weight of DDVP respectively for 28 days. DDVP administration significantly reduced (P<0.05) the alkaline phosphatase activity in the liver and kidney with corresponding increases in the serum. Acid phosphatase activity increased significantly (P<0.05) in liver and kidney, while there was no significant change (P>0.05) in the serum acid phosphatase activity. There was also a significant decrease (P<0.05) in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in the liver and kidney. Liver and kidney levels of GSH, vitamins C and E were also significantly reduced (P<0.05). Serum malonidialdehyde and lipid hydroperoxide also increased significantly (P<0.05) in all DDVP treated groups. The available data from this study revealed that DDVP brings about its toxicity through depletion of the antioxidant systems and thus exposing the cells and cellular macromolecules to oxidative attacks by reactive oxygen species generated either from its metabolites or other in vivo means.

• Authors: Taofeek Olakunle Ajiboye
• Journal: Chemico-biological interactions (Chem Biol Interact) Vol. 185 Issue 3 Pg. 202-7 (May 14 2010) ISSN: 1872-7786 [Electronic] Ireland
• PMID: 20302853 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antioxidants
• Insecticides
• Vitamin E
• Dichlorvos
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione Reductase
• Alkaline Phosphatase
• Acid Phosphatase
• Glutathione
• Ascorbic Acid

Topics

• Acid Phosphatase (metabolism)
• Alkaline Phosphatase (metabolism)
• Animals
• Antioxidants (pharmacology)
• Ascorbic Acid (metabolism)
• Catalase (metabolism)
• Dichlorvos (pharmacology)
• Dose-Response Relationship, Drug
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Glutathione Reductase (metabolism)
• Insecticides (pharmacology)
• Kidney (drug effects, enzymology, metabolism)
• Lipid Peroxidation (drug effects)
• Liver (drug effects, enzymology, metabolism)
• Male
• Oxidation-Reduction
• Random Allocation
• Rats
• Rats, Wistar
• Superoxide Dismutase (metabolism)
• Vitamin E (metabolism)